Industrial equipment can be elevated and supported in structures or at grade on foundations depending on equipment operations, process requirements, or construction methods used in modularization. It is required to consider each stage in the life of the equipment–including transportation and installation, operating loads and temperature changes, process upset conditions, environmental loads, and maintenance requirements–for the design of supporting structures. The support types and connections for equipment can be arranged differently because of the varying operating requirements for each piece of equipment. Structure behavior can be complicated for a group of equipment interconnected with mechanical systems, which may be supported on elevated structures, at grade or on separate structures connected by large size pipes or ducts, particularly for those equipment and mechanical systems supported by tall structures. It is essential to coordinate among engineering disciplines and vendor suppliers to achieve successful equipment supporting system design. This paper discusses design considerations for equipment support structures. Considerations include interactions between equipment and supporting structures, structural framing system selection, analysis model types, structural rigidity, design loads, and framing connections. Case studies of analysis modeling, brace layout comparison, connections between equipment and structural supports, load paths from equipment to supporting structures, structure natural frequencies, and structure to foundation connections are included and discussed.